CELLULITE PREDISPOSITION TEST
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Cellulite is a very common, harmless skin condition that causes lumpy, dimpled flesh on the
thighs, hips, buttocks and abdomen. The condition is most prevalent in women. Little is known
about what causes cellulite. It involves fibrous connective cords that tether the skin to the
underlying muscle, with the fat lying between. As fat cells accumulate, they push up against the
skin, while the long, tough cords pull down. This creates an uneven surface or dimpling.In
addition, hormonal factors play a large role in the development of cellulite, and genetics
determine skin structure, skin texture and body type. Other factors, such as weight and muscle
tone affect whether you have cellulite, though even very fit people can have it. Cellulite is much
more common in women than in men. In fact, most women develop some cellulite after puberty.
This is because women’s fat is typically distributed in the thighs, hips and buttocks — common areas for cellulite. Cellulite is also more common with aging, when the skin loses elasticity.
Weight gain can make cellulite more noticeable, but some lean people have cellulite, as well. It
tends to run in families, so genetics might play the biggest role in whether you develop cellulite.
Recent studies show that polymorphisms in the ACE gene rs1799752 and the HIF1A gene rs11549465 are responsible for the appearance of cellulite independent of lifestyle, weight and contraceptives.
Polymorphisms in the ACE gene lead to elevated enzyme levels with alterations in blood circulation to the skin leading to abnormal cell proliferation and altered tissue architecture. Polymorphisms in the HIF1A gene cause cellulite, especially in thin women. It should be noted that the polymorphisms in the mentioned genes are associated with cellulite, including in normal-weight women. Increased basal inflammation can also contribute to cellulite, which is why analyzing polymorphisms in the Il and TNF genes is crucial. Based on the results, our experts will recommend genocosmetics adapted to your genetic profile, diet and supplements that will help you fight cellulite.
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